Crema Cathedral (Italian: Duomo di Crema, Cattedrale di Santa Maria Assunta) is a Roman Catholic cathedral in Crema, northern Italy. Dedicated to the Assumption of the Virgin Mary, it is the seat of the Bishop of Crema.

The first cathedral in the town was destroyed by Frederick Barbarossa in 1160. A new building was begun in 1185, but construction was halted in 1212, not to begin again until 1284 but in Gothic style. The church was finished in 1340, with the addition in 1385 of a lengthened apse and a crypt.